Cheating evolution: engineering gene drives to manipulate the fate of wild populations
نویسندگان
چکیده
منابع مشابه
Engineering the Wild: Gene Drives and Intergenerational Equity
New genetic engineering methods are allowing scientists to insert genes into organisms that have the potential to spread themselves throughout natural populations upon the release of individuals carrying those genes. Gene drive technology is being researched and developed for purposes of reducing or eliminating human, ecological or agricultural pest populations, or immunizing other desirable or...
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An ideal gene drive system to alter wild populations would 1) exclusively affect organisms within the political boundaries of consenting communities, and 2) be capable of restoring any engineered population to its original genetic state. Here we describe 'daisy quorum' drive systems that meet these criteria by combining daisy drive with underdominance. A daisy quorum drive system is predicted t...
متن کاملACCEPTED MANUSCRIPT Concerning RNA-guided gene drives for the alteration of wild populations
Introduction Natural Gene Drives Endonuclease Gene Drives Engineered Gene Drives RNA-guided Genome Editing Via the Cas9 Nuclease Will RNA-Guided Gene Drives Enable Us to Edit the Genomes of Wild Populations? Cutting Specificity Copying Evolutionary Stability Development Time Gene Drive Limitations Safeguards and Control Strategies Reversibility Immunization Precisely Targeting Subpopulations Li...
متن کاملConcerning RNA-guided gene drives for the alteration of wild populations
Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve as a general method for spreading altered traits through wild populations over many generations. We detail l...
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abstract because of the many geopolitical, geo economical and geo strategically potentials and communicational capabilities of eco region, members can expand the convergence and the integration in base of this organization that have important impact on members development and expanding peace in international and regional level. based on quality analyzing of library findings and experts interv...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2016
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg.2015.34